Clinical Research

TITLE/YEAR
lrabon IS & Oblepias, EGC (2011)

TITLE/DESIGN
Effects of oral reduced glutathione treatment on semen characteristics of male infertility patients with oligozoospermia: A randomized, placebo-controlled trial.

RESULT/CONCLUSION
Oral reduced glutathione therapy demonstrated a statistically significant positive effect on total sperm count and Absolute total motile sperms, but no Significant effect on percent motility And morphology.

The findings of this study indicate that Oral glutathione therapy could be Potential treatment for oligozoospermia.

REFERENCE
lrabon IS, Oblepias EGC. Effects of Oral Reduced Glutathione Treatment on Semen Characteristics of Male Infertility: A Randomized, Placebo-controlled Trial. Philippine Journal of Obstetrics & Gynecology. Vol. 35 No. 1, March 2011

TITLE/YEAR
Calogero et. al. (2017)

TITLE/DESIGN
Conservative Non hormonal Options for the Treatment of Male Infertility: Antibiotics, Anti-Inflammatory Drugs and Antioxidants.

RESULT/CONCLUSION
Significant levels of glutathione have been demonstrated in the testes, epi­didymis, seminal fluid and spermatozoa.

Reduced glutathione & its associated enzyme glutathione peroxidase (GPX) provide the main endogenous anti­oxidant protective mechanism against OS in the epididymis and testes.

REFERENCE
Calogero et.al. Conservative Nonhormonal Options for the Treatment of Male Infertility: Antibiotics, Anti-Inflammatory Drugs and Antioxidants. BioMed Research International Vol 2017, Article ID 4650182, 17 pages.

TITLE/YEAR
Lenzi A. et. al. (1993)

TITLE/DESIGN
Placebo-controlled, double-blind, cross-over trial of glutathione therapy in male infertility.

RESULT/CONCLUSION
Positive effect on total motility, particu­larly on the percentage of forward motility; Increased velocity of motile sperm. Positive effect on sperm morphology.

Potential therapeutic option for dy­spermia associated with unilateral varicocele or germ-free genital tract inflammation.

REFERENCE
Lenzi A. et. al. Placebo-controlled, double-blind, cross-over trial of glutathione therapy in male infertility. Hum Reprod. 1993 Oct; 8: 1657-62.

TITLE/YEAR
Tola EN. Et. al. (2013)

TITLE/DESIGN
Intracellular Ca2+ and antioxidant values induced positive effect on fertilization ratio and oocyte quality of granulosa cells in patients undergoing in-vitro fertilization.

RESULT/CONCLUSION
Glutathione (P<0.05), cytosolic Ca and oocyte quality (P<0.001) values were higher in the fertilized group.

High glutathione and cytosolic Ca con­centrations in granulosa cells of patient undergoing IVF increase the fertilization potential of oocyte.

REFERENCE
Tola EN. et. al. Intracellular Ca2+ and antioxidant values induced positive effect on fertilization ratio and oocyte quality of granulosa cells in patients undergoing in-vitro fertilization. Reprod Fertil Dev. 2013; 25(5): 746-52.

TITLE/YEAR
Takuji Nishihara et. al. (2018}

TITLE/DESIGN
Evaluation of antioxidant status and oxidative stress markers in follicular fluid for human in-vitro fertilization outcome.

RESULT/CONCLUSION
Total GSH levels were lower and 8- OHdG levels were higher in patients who had low fertilization rates after lntracytoplasmic sperm injection (ICSI}

Total GSH and 8-OHdG in human follicular fluid is a potential marker for fertilization in Assisted Reproductive Technology (ART}.

REFERENCE
Takuji Nishihara et. al. Evaluation of antioxidant status and oxidative stress markers in follicular fluid for human in-vitro fertilization outcome. Reprod Med Biol. 2018; 17: 481-846.